Well, I've got what may be bad news for you, Jayson. There isn't a heckuva lot you can do. Except get used to it.
See, the thing is, I don't know how many bike saddles I've used over the yearstwo dozen or more. Doesn't seem like any of them is that good at first. But over time they break in a little bit (not reallynot these days with synthetics) or my butt just gets accustomed. I think mostly the latter.
That said, you don't need to be totally passive about it. If your bike cost less than $1,200, chances are it has kind of a cheap no-name saddle on it. So you can upgrade and try something like a WTB Rocket V Pro ($165). It has a little rise in the tail to give you some support, a cut-out where your most sensitive parts are located, and a flexible shell. I have a WTB saddle on my Marin dualie and I've done several four- to five-hour rides.
Good shorts also help. Try some Zoic Ether ($66). They're a nice-looking short with a decent chamois pad. If you wear undershorts, make sure they are absorbent, fast-drying, and flat-seamed. Patagonia's Men's Active Sport Briefs ($29) fill the bill.
As for things to put on your skinI dunno about Vaseline, but people have had good results with Paceline Chamois Butt'R ($15 for a tube). It'll help reduce friction.
So there you go. I hope you sit more easily soon. But time will indeed make even the gnarliest saddle a bit more comfortable.