Taca (800-535-8780) will get you there out of Los Angeles and Lacsa (800-225-2272) has a flight out of New Orleans.
Once within the country flights are relatively cheap, $20-45, to get from Tegucigalpa to La Ceiba or out to the islands. Reservations however must be made within the country and can be scarce during the heavily trafficked Christmas season.
Rental cars are available, but can be expensive. Four-wheel drive or heavy trucks are advised because while the highways are maintained, side roads are not and most of the best adventuring will be off road.
Lodging is easy to come by and in addition to the hotels, there are private rooms that can be discovered with just a little imagination.
Health and safety
Crime is not a huge problem, nor is it negligible. During my stay, there was an incident along the river where a woman was mugged. Be mindful of your neighbors, watch your belongings, and you won't have a problem.
Tofino Expeditions operates ocean kayaking expeditions on the Caribbean coast of Honduras, as well as jungle river trips in the Rio Platano Biosphere Reserve. For information, Tofino Expeditions can be reached at: 604-687-4455 (phone), 604-687-8525 (fax), email@example.com (e-mail), or Web page: http://vanbc.wimsey.com/~tofinoex/.