The Shuttle's DWR-coated, heavy-duty nylon fabric is virtually impervious to weather. On a Colorado road trip, I overloaded it with 70 pounds of hike 'n' bike gear, lashed its D-rings to my truck's rack, and found that everything remained dry despite several afternoon thunderstorms. And when it tumbled off the roof, the Shuttle's rigid structure and foam paddingon both the bottom and side panelsprotected even the most delicate contents (namely a '72 cabernet). It's chiefly one big (4,800-cubic-inch) bag, but a top lid and interior mesh pocket are perfect for keeping bike tools, digital cameras, or anything else that can easily be lost or damaged. patagonia.comBonus: A reflective lining takes the mystery out of finding items at night.Bummer: End handles could use some padding.