Boundary Prima Pack
So many backpacks look and work the same. The Prima ($200), however, is a thoughtful redesign. The main zipper is right in the middle, instead of along the edges, so you can flare the bag open for easy access. Inside, at the bottom, there's a smaller removable camera bag for your body and lenses. There's also a removable sleeve that holds your laptop and organizes your cords and work essentials.
The outer is made from 750-denier, water-resistant fabric. It's also got waterproof zippers and one-hand-compatible magnetic buckles.